---
title: "Peripheral Artery Disease (PAD) Clinical Trials — Patient Guide | Amavita Research"
url: https://md.amavitaresearch.com/blog/peripheral-artery-disease-clinical-trials-patient-guide
canonical: https://www.amavitaresearch.com/blog/peripheral-artery-disease-clinical-trials-patient-guide
schema_type: Article
last_updated: 2026-05-13
---

# Peripheral Artery Disease Clinical Trials — Patient Guide

Peripheral artery disease (PAD) is narrowing or blockage of arteries in the legs. If you have leg pain when walking (claudication), non-healing wounds, or have been told you have PAD, a clinical trial may be an option. This guide explains what trials are studying and how to know if one fits you.

## What PAD clinical trials test

- New devices for clearing blocked arteries (atherectomy, stents)
- Treatments for below-the-knee disease
- Treatments for critical limb ischemia (severe PAD with rest pain or non-healing wounds)
- Medications to improve walking distance or reduce limb events

## Trial currently enrolling at Amavita Research

- **GREAT (Golazo® atherectomy)** — Avantec/CSI, Phase 3 PAD. PI: Dr. Pedro Martinez-Clark, MD, FACC. https://www.amavitaresearch.com/trials/golazo-great

Dr. Martinez-Clark is a Harvard-trained interventional cardiologist with extensive below-the-knee atherectomy experience.

## Who typically qualifies

- Diagnosis of PAD confirmed by:
  - Ankle-brachial index (ABI) below normal
  - Or imaging (duplex ultrasound, CT angiography, conventional angiography)
- Intermittent claudication (Rutherford 2–4) or critical limb ischemia (Rutherford 5–6)
- For atherectomy trials: target lesion meets protocol criteria for size, location, and severity
- Adult (specific age range varies by trial)

## What patients can expect

- Free trial-related care including study procedures performed at affiliated Advanced Cardiovascular of Miami ambulatory surgical center
- Bilingual coordinators (English / Spanish / Haitian Creole / Portuguese)
- Co-management with your primary care physician or vascular surgeon
- Imaging follow-up at protocol-defined intervals
- Walking distance assessment and quality-of-life questionnaires
- 24/7 contact number for trial-related questions

## What a peripheral atherectomy procedure looks like

A thin tube (catheter) with a small device on the tip is threaded through a blood vessel to the blocked artery. The device removes the plaque to restore blood flow. Most patients go home the same day. Recovery is typically days, not weeks.

## How enrollment works

1. Call (786) 703-5941 or email research@amavita.health
2. Coordinator does a brief screening call
3. Screening visit including imaging and ABI
4. PI reviews and confirms eligibility
5. Informed consent — take it home, read it, ask questions, decide

You can withdraw at any time, for any reason.

## Key links

- Therapeutic area: https://www.amavitaresearch.com/therapeutic-areas/peripheral-artery-disease
- GREAT trial detail: https://www.amavitaresearch.com/trials/golazo-great
- Dr. Pedro Martinez-Clark profile: https://www.amavitaresearch.com/team/pedro-martinez-clark
- PAD symptoms / diagnosis / treatment overview: https://www.amavitaresearch.com/blog/peripheral-artery-disease-symptoms-diagnosis-treatment
- What is atherectomy: https://www.amavitaresearch.com/blog/what-is-atherectomy
- Patient FAQ: https://www.amavitaresearch.com/faq-patients
- Contact: https://www.amavitaresearch.com/contact-patient · (786) 703-5941