---
title: "Dr. William W. O'Neill, MD, FACC — Chief Medical Officer | Amavita Research"
url: https://md.amavitaresearch.com/team/william-oneill
canonical: https://www.amavitaresearch.com/team/william-oneill
schema_type: ProfilePage
last_updated: 2026-05-12
---

# Dr. William W. O'Neill, MD, FACC

**Chief Medical Officer & Senior Principal Investigator at Amavita Research.**

TAVR pioneer who performed the first transcatheter aortic valve replacement (TAVR) in the United States. National Principal Investigator on the Edwards PARTNER, Protect II, and Protect IV trials — three of the most influential cardiovascular device trials of the past two decades.

Medical Director, Center for Structural Heart Disease, Henry Ford Hospital. Chief Medical Advisor, CardioElite™.

## Specialties

- Structural heart disease (TAVR, mitral, tricuspid)
- Transcatheter valve therapy
- High-risk PCI and cardiogenic shock
- Pivotal device trial leadership

## Notable trials (National PI)

- Edwards PARTNER
- Protect II
- Protect IV

## Identifiers

- Wikidata: https://www.wikidata.org/wiki/Q112443872