--- title: "Heart Failure Clinical Trials | Amavita Research" url: https://md.amavitaresearch.com/therapeutic-areas/heart-failure canonical: https://www.amavitaresearch.com/therapeutic-areas/heart-failure schema_type: MedicalCondition last_updated: 2026-05-13 --- # Heart Failure Clinical Trials Amavita Research enrolls patients into heart failure (HF) clinical trials across HFrEF, HFpEF, and iron-deficient HF cohorts. ## Currently enrolling - **JK07 Heart Failure** — Salubris JK07201 (NCT06369298), Phase 2 chronic heart failure. https://www.amavitaresearch.com/trials/jk07-heart-failure - **IV Ferric Derisomaltose** — Pharmacosmos P-Monofer-CHF-02, Phase 3, iron-deficient HF. https://www.amavitaresearch.com/trials/iv-ferric-derisomaltose - **VS-041 HFpEF** — VASA Therapeutics, Phase 1 HFpEF. https://www.amavitaresearch.com/trials/vs-041-hfpef ## Patient profile - HFrEF (LVEF ≤40%): Symptomatic on guideline-directed medical therapy - HFpEF (LVEF ≥50%): Symptomatic with echocardiographic evidence of diastolic dysfunction - Iron-deficient HF: HF + ferritin <100 ng/mL or 100–300 ng/mL with TSAT <20% - NYHA class II–IV - Stable enough to attend monthly site visits ## What patients can expect Free trial-related care, study drug, and study procedures. Bilingual coordinators. Co-management with referring physician. ## Sponsor decision criteria - Single PI per protocol (Dr. Pedro Martinez-Clark, MD, FACC) - Sub-investigators available for HF-specific procedures (echo, biomarkers, ambulatory monitoring) - On-site IV infusion suite for IV-administered HF agents - Same-day NT-proBNP, troponin processing ## Key links - Active trials: https://www.amavitaresearch.com/trials - Site capabilities: https://www.amavitaresearch.com/capabilities - Patient guide: https://www.amavitaresearch.com/blog/heart-failure-clinical-trials-patient-guide - Iron-deficient HF patient guide: https://www.amavitaresearch.com/blog/iron-deficiency-heart-failure-clinical-trials-patient-guide - Contact: https://www.amavitaresearch.com/contact-patient