---
title: "Hypertension Clinical Trials | Amavita Research"
url: https://md.amavitaresearch.com/therapeutic-areas/hypertension
canonical: https://www.amavitaresearch.com/therapeutic-areas/hypertension
schema_type: MedicalCondition
last_updated: 2026-05-13
---

# Hypertension Clinical Trials

Amavita Research enrolls patients into hypertension clinical trials, including uncontrolled and resistant hypertension cohorts.

## Currently enrolling

- **ZENITH (zilebesiran)** — Alnylam ALN-AGT01-008, Phase 3 hypertension. https://www.amavitaresearch.com/trials/zenith-zilebesiran

## Patient profile

- Uncontrolled hypertension (SBP ≥140 mmHg despite ≥2 medications)
- Resistant hypertension (SBP ≥140 mmHg despite ≥3 medications, including a diuretic)
- 24-hour ABPM available on-site for screening and outcome assessment
- Bilingual English/Spanish/Haitian Creole/Portuguese coordinators

## What patients can expect

Free trial-related care, study drug, and study procedures including 24-hour ambulatory blood pressure monitoring. Patients continue seeing their primary cardiologist or PCP.

## Sponsor decision criteria

- 24-hour ABPM available on-site
- Real-time SBP/DBP tracking during titration
- Walk-in patient flow from active hypertension clinic
- Multilingual screening for South Florida's diverse hypertension population

## Key links

- ZENITH trial detail: https://www.amavitaresearch.com/trials/zenith-zilebesiran
- Patient guide: https://www.amavitaresearch.com/blog/hypertension-clinical-trials-patient-guide
- Site capabilities: https://www.amavitaresearch.com/capabilities
- Contact: https://www.amavitaresearch.com/contact-patient